Efficacy and Safety
نویسنده
چکیده
273 The thrust in oral drug therapy of type 2 diabetes mellitus has been to make it safer (fewer adverse effects), convenient (once daily administration) and at the same time delay development of secondary failure to sulfonylureas. Sulfonylureas have been used for type 2 diabetes mellitus for over 50 years and are still the leading class of oral hypoglycemic agent. Concerns about cardiovascular events have come up time and again. However data from UKPDS and others have confirmed the safety of sulfonylureas. The first sulfonylurea was introduced in the early ‘50s in the management of type 2 diabetes mellitus (and needed to be administered with each meal). Glibenclamide, glipizide and gliclazide were subsequently added and glimiperide (once daily sulfonylureas) was added to the armamentarium in the mid ‘90s. Thereafter there have been developments in drug delivery technology so that the shorter acting sulfonylureas can be also administered once daily.
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